Polynucleotides vs. Profhilo: Which Treatment Suits You Best?

By Dr. Raquel Amado on the 14th September 2023

Polynucleotides and Profhilo are two very effective and popular treatments in aesthetics and anti-ageing. These treatments are unique, with individual benefits catering to different needs. 


So which is the best treatment for you? In this blog, we will explore the differences and similarities between Polynucleotides and Profhilo to help you make an informed decision.


Profhilo and Polynucleotides may seem similar at first glance, but they operate differently, and each offers unique benefits.


Understanding Profhilo: A Moisturising Marvel


Profhilo, often hailed as a moisturising marvel works as an injectable treatment aimed at bio-remodelling your skin. This means it’s designed to stimulate collagen production and enhance hydration levels. The treatment involves precisely injecting Profhilo into multiple points on your face and neck, targeting areas that could benefit from improved moisture and collagen support. 


Using ultra-pure hyaluronic acid, it can give your skin a very quick glow and will stimulate your collagen at a later stage. Your body will need time to produce the collagen, so you can expect to see these results around 4-6weeks after your appointment. 

When performed on a regular basis of every 3 months, the results are maintained and you will have a permanent glow and even tighter skin.


Unveiling Polynucleotides: A Regenerative Revolution


On the other side of the ring, we have Polynucleotides, a regenerative powerhouse. These treatments focus on enhancing the overall health of your skin cells by stimulating the production of critical substances like hyaluronic acid, elastin, and collagen. The magic of Polynucleotides is that it makes the cells rejuvenate, so your own skin will be able to work better. You will see reduced pore size, inflammation and pigmentation as your skin produces its own your own hyaluronic acid, collagen and elastin.


It takes longer to see results from Polynucleotides than Profhilo, because we need to wait for the body to work its magic. 


While Profhilo gives hydration straight away, there are several concern areas it cannot treat which can instead use Polynucleotides including:


  • under eye
  • forehead 
  • paper lip lines

Choosing Your Champion: Profhilo or Polynucleotides?


So, the million-dollar question is: which treatment is the right match for you? Well, the answer isn’t one-size-fits-all. It largely depends on your unique skin care needs and the goals you hope to achieve.

Dr Raquel performing Polynucleotides treatment on a patient seeking healthier skin

Dr Raquel performing Polynucleotides treatment on a patient seeking healthier skin


If you’re seeking…


  1. Improved Hydration and Collagen Production: Profhilo might be the contender you’re looking for. Its specialised formula excels at boosting hydration and collagen production, resulting in skin that’s not only more moisturised but also firmer and more youthful.


  1. Overall Cellular Health Enhancement: On the other hand, if your focus is on enhancing the overall health of your skin cells, Polynucleotides could be your winning choice. By helping your skin to rejuvenate itself, Polynucleotides work their regenerative magic, promoting the production of vital substances like hyaluronic acid, elastin, and collagen.


Before and after of Polynucleotide treatment

Before and after of Polynucleotide treatment around the eye area. Pictures courtesy of DermaFocus UK



Introductory offer September only:

1 area – 2 sessions for £570 – saving £80

2 areas – 2 sessions for £800 – saving £500

3 areas – 2 sessions for £950 – saving £100


3 session packages for ideal results:

1 area – 3 sessions for £855 – saving £120

2 areas – 3 sessions for £1200 – saving £750

3 areas – 3 sessions for £1425 – saving £1500


Usual price per session: £325

Making Your Decision on Polynucleotides vs. Profhilo


Whether you lean towards the moisture-boosting prowess of Profhilo or the regenerative wonders of Polynucleotides, both treatments have their merits. To determine which one aligns best with your goals and aspirations, consider reaching out to us for a personalised consultation. We’re here to help you make the best choice for your skin.


Got questions or ready to get started? Give us a call at  01732 525875, email hello@skinandmedicalcosmetics.co.uk or book your consultation directly HERE.