Polynucleotides (PNs) vs Exosomes

By Dr. Raquel Amado on the 02nd May 2024

In the ever-evolving field of aesthetic medicine, two innovative treatments stand out for their unique approach to skin rejuvenation: Polynucleotides (PNs) and Exosomes. These advanced therapies delve beyond the surface, offering solutions that stimulate the body’s natural healing and regeneration capabilities. PNs, with their pivotal role in cellular repair and regeneration, promise enhanced skin texture and resilience. Exosomes, the body’s cellular messengers, harness the power of intercellular communication to rejuvenate and repair skin at a molecular level. This blog will explore the science behind these treatments, shedding light on how they offer a promising future for those seeking to rejuvenate their skin from within.


What are Polynucleotides (PNs)?

Polynucleotides (PNs) are large molecules composed of DNA fragments , fundamental  for repair and regeneration. They are extracted from natural sources tailored for medical use. In aesthetic medicine, PNs play a crucial role by promoting the regeneration of skin cells, enhancing collagen production for elasticity,  improving hydration for overall skin health, as well as improving pigmentation and reducing inflammation. Research and case studies highlight their effectiveness and safety, showing significant improvements in skin quality and texture, making them an amazing  option for non-invasive skin rejuvenation treatments.


What are Exosomes?

Exosomes are tiny vesicles secreted by cells, playing a pivotal role in intercellular communication. They carry proteins, RNA, and growth factors and other essential nutrients to target cells, facilitating repair and regeneration processes. In the realm of aesthetic medicine, exosomes are applied to enhance skin rejuvenation, leveraging their natural ability to promote healing. Studies support their effectiveness in improving skin texture, elasticity, and overall appearance, marking them as a safe and innovative option for topical  skin treatments, with ongoing research promising to unlock further potential.


Exosomes and polynucleotides are both innovative aesthetics treatments with promising applications in regenerative medicine and cosmetic procedures. Here’s a comparison of their benefits:

1. Regenerative Potential:

Exosomes: Employed in rejuvenating and preventing skin ageing Exosomes serve a crucial function in intercellular communication. These minute messengers, sourced from stem cells, are abundant in growth factors, proteins, and genetic material, fostering tissue renewal, bolstering collagen synthesis, and enhancing overall skin texture.

Polynucleotides: Utilized in rejuvenating and preventing skin ageing Polynucleotides, organic compounds sourced from salmon or trout DNA, possess the capacity to activate cellular restoration and rejuvenation. They can foster collagen generation, enhance skin flexibility, and diminish the visibility of fine lines and wrinkles.

2. Delivery:

Exosomes: Exosomes are delivered by topical application in association with microneedling, laser or radiofrequency with microneedling.

Polynucleotides: Polynucleotides are  delivered directly into tissues via injections.

3. Therapeutic Applications:

Minimizing Signs of Aging
Boosting Skin Hydration and Texture
Targeting Scarring
Addressing Sun Damage
Revitalizing Overall Skin Well-being: Beyond addressing specific concerns, polynucleotides and exosomes are treatments that offer comprehensive skin revitalization. They enhance the overall health and vibrancy of the skin, resulting in a refreshed appearance.

In summary, both exosomes and polynucleotides offer unique advantages and complementary benefits in regenerative medicine and cosmetic procedures.


Book Online Or Get In Touch

Elevate your skincare journey with Polynucleotides treatment with Dr Raquel. Book your consultation at Dr Raquel Skin and Medical Cosmetics today. Contact us at 01732 525875 or drop us an email at hello@skinandmedicalcosmetics.co.uk.